Primer día, 31,8% no tienen ventilación mecánica (VM), 13,1% tienen VM no invasiva y 55,1% VM invasiva. Un total de 956 patientes incluidos 63,9% hombres edad mediana 68 años. Registramos los antecedentes personales, juicio clínico, datos durante ingreso en UCI, puntuaciones de severidad en el primer día y durante evolución dos variables calculadas: PaFi and Grad(A-a)O 2. Todos los pacientes de cuidados intensivos, con o sin daño pulmonar. DiseñoĮstudio observacional usamos una regresión lineal para realizar un estudio multivariable y mejorar la fórmula de la PaFi teniendo en cuenta la PEEP. Valorar si el gradiente alveolo-arterial de oxígeno (GradO 2) ayuda a confirmar la influencia de la PEEP en la PaFi (PaO 2/FiO 2). Conclusionsīy adding PEEP to the PaFi model (PaFip), we clearly improve the latter, as reflected by a better goodness of fit. Only PaFi remained in the model, and was discretely complemented by APACHE IV R 2 = 0.8. We performed linear regression (dependent variable: GradO 2) and used PaFip instead of PaFi. Correlation index between PaFip and Grad(A-a)O 2: −0.9 ( p < 0.001).
#AA GRADIENT PLUS#
We changed the PaFi formula, referring to it as PaFip (PaFi plus PEEP): Ln (PaFi/). On performing multiple regression (dependent variable: GradO 2), the following variables were included in the model: PaFi, PEEP, APACHE IV and SOFA coefficient of determination ( R 2) of 0.62 without PEEP and 0.72 with PEEP. We observed a correlation (Pearson) between Grad(A-a)O 2 and PaFi of −0.84 ( p < 0.001). On the first day, 31.8% did not have mechanical ventilation (MV), 13.1% had non-invasive MV and 55.1% had invasive MV. ResultsĪ total of 956 patients were included: 63.9% men median age 68 years. Two calculated variables: PaFi and Grad(A-a)O 2. We recorded personal history, clinical judgment, intensive care data, severity scores on the first day and progression. We included all patients who were admitted to the intensive care unit, regardless of pulmonary damage.
Observational study we used linear regression to perform a multivariate study to improve the PaFi formula by taking PEEP into account. To determine whether the alveolar-arterial oxygen gradient (GradO 2) helps confirm the influence of PEEP on PaFi (PaO 2/FiO 2).
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